Downregulation of miR-205 and miR-31 confers resistance to chemotherapy-induced apoptosis in prostate cancer cells
نویسندگان
چکیده
منابع مشابه
Downregulation of Mir-31, Mir-155, and Mir-564 in Chronic Myeloid Leukemia Cells
BACKGROUND/AIMS MicroRNAs (miRNAs) are short non-coding regulatory RNAs that control gene expression and play an important role in cancer development and progression. However, little is known about the role of miRNAs in chronic myeloid leukemia (CML). Our objective is to decipher a miRNA expression signature associated with CML and to determine potential target genes and signaling pathways affe...
متن کاملMicroRNA Profiling in Prostate Cancer - The Diagnostic Potential of Urinary miR-205 and miR-214
Prostate cancer (PCa) is the most common type of cancer in men in the United States, which disproportionately affects African American descents. While metastasis is the most common cause of death among PCa patients, no specific markers have been assigned to severity and ethnic biasness of the disease. MicroRNAs represent a promising new class of biomarkers owing to their inherent stability and ...
متن کاملmiR-29b, miR-205 and miR-221 Enhance Chemosensitivity to Gemcitabine in HuH28 Human Cholangiocarcinoma Cells
BACKGROUND AND AIMS Cholangiocarcinoma (CCA) is highly resistant to chemotherapy, including gemcitabine (Gem) treatment. MicroRNAs (miRNAs) are endogenous, non-coding, short RNAs that can regulate multiple genes expression. Some miRNAs play important roles in the chemosensitivity of tumors. Here, we examined the relationship between miRNA expression and the sensitivity of CCA cells to Gem. ME...
متن کاملmiR-17/20 sensitization of breast cancer cells to chemotherapy-induced apoptosis requires Akt1
The serine threonine kinase Akt1 has been implicated in the control of cellular metabolism, survival and growth. Herein, disruption of the ubiquitously expressed member of the Akt family of genes, Akt1, in the mouse, demonstrates a requirement for Akt1 in miRNA-mediated cellular apoptosis. The miR-17/20 cluster is known to inhibit breast cancer cellular proliferation through G1/S cell cycle arr...
متن کاملMiR-181a contributes to bufalin-induced apoptosis in PC-3 prostate cancer cells
BACKGROUND Bufalin is a major active compound of cinobufacini, which comes from dried toad venom and has been used for treatments of various cancers in China for many years. A number of studies have demonstrated that bufalin can induce apoptosis in some cancers. However, effects and mechanism of bufalin on prostate cancer cells remain unknown. METHODS Apoptosis assay was measured by the annex...
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ژورنال
عنوان ژورنال: Cell Death & Disease
سال: 2010
ISSN: 2041-4889
DOI: 10.1038/cddis.2010.85